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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB1
All Species:
52.42
Human Site:
Y472
Identified Species:
88.72
UniProt:
P08238
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08238
NP_031381.2
724
83264
Y472
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y481
E
M
V
S
L
K
D
Y
C
T
R
M
K
E
N
Rhesus Macaque
Macaca mulatta
XP_001098520
724
83571
Y472
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
Y472
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Rat
Rattus norvegicus
P34058
724
83263
Y472
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
Y564
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Chicken
Gallus gallus
Q04619
725
83409
Y473
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
S
Frog
Xenopus laevis
NP_001086624
722
82939
Y470
E
M
A
S
L
T
E
Y
V
S
R
M
K
E
N
Zebra Danio
Brachydanio rerio
O57521
725
83339
Y471
E
M
T
S
L
T
E
Y
V
S
R
M
K
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
Y465
D
F
C
S
L
A
D
Y
V
S
R
M
K
D
N
Honey Bee
Apis mellifera
XP_395168
718
82735
Y468
E
V
C
S
L
K
D
Y
V
G
R
M
K
E
N
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y450
E
P
T
S
L
K
E
Y
V
S
R
M
K
E
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
Y452
E
M
T
S
F
K
D
Y
V
T
R
M
K
E
G
Baker's Yeast
Sacchar. cerevisiae
P02829
709
81388
Y460
E
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86
95.1
N.A.
N.A.
99.1
99.5
N.A.
86.8
94.7
92.4
91.4
N.A.
78.4
81.3
75.4
N.A.
Protein Similarity:
100
93.4
96.1
N.A.
N.A.
99.5
99.8
N.A.
87.5
97.7
96.6
97
N.A.
88.5
89.9
86.8
N.A.
P-Site Identity:
100
60
100
N.A.
N.A.
100
100
N.A.
100
93.3
80
86.6
N.A.
53.3
60
80
N.A.
P-Site Similarity:
100
73.3
100
N.A.
N.A.
100
100
N.A.
100
100
86.6
93.3
N.A.
80
73.3
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
69.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
83.8
78.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
15
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
36
0
0
0
0
0
0
8
0
% D
% Glu:
93
0
0
0
0
0
65
0
0
0
0
0
0
93
0
% E
% Phe:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
29
0
0
0
0
0
0
93
0
0
% K
% Leu:
0
8
0
0
93
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
72
0
0
0
0
0
0
0
0
0
100
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
43
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
100
0
0
0
0
% R
% Ser:
0
0
0
100
0
43
0
0
0
72
0
0
0
0
8
% S
% Thr:
0
0
72
0
0
22
0
0
0
22
0
0
0
0
36
% T
% Val:
0
8
8
0
0
0
0
0
93
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _